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. 2024 Aug 31;14:20292. doi: 10.1038/s41598-024-71259-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — Network pharmacological analysis. (A) Venn diagrams of potential targets of Ber and OA. (B) The top 5 items from GO enrichment including Biological process (BP), Cellular component (CC), Molecular function (MF). (C) Core targets screening in the PPI network. (D) Molecular docking between Ber and Caspase3. Molecular docking between Ber and MMP13. (E) The docking energy between Ber and its potential targets. OA, osteoarthritis; Ber, Bergenin.