Table 2.

Criteria for Diagnosis of Complete Retinal Pigment Epithelium and Outer Retinal Atrophy on Optical Coherence Tomography and Confirmatory Findings on Other Imaging Methods

Optical Coherence Tomography	Fundus Autofluorescence	Near-Infrared Reflectance	Color/Multicolor
Zone of hypertransmission of ≥250 μm	Sharply demarcated borders	Sharply demarcated borders	Sharply demarcated borders
Zone of attenuation or disruption of RPE band of ≥250 μm	Hypoautofluorescent: black level similar to optic nerve head or retinal blood vessels*	Hyperreflective	Hypopigmentation
Evidence of overlying photoreceptor degeneration whose features include ONL thinning, ELM loss, and EZ or IZ loss	Diameter, ≥250 μm (area, 0.05 mm2)	Diameter, ≥250 μm (area, 0.05 mm2)	Increased visibility of choroidal vessels
Exclude: scrolled RPE or other signs of RPE tear	Exclude: macular pigment or other artifact	Exclude: artifact	Diameter, ≥250 μm (area, 0.05 mm2)

ELM = external limiting membrane; EZ = ellipsoid zone; IZ = interdigitation zone; ONL = outer nuclear layer; RPE = retinal pigment epithelium.

^*If trickling junctional autofluorescence pattern is present or refractile drusen deposits or residual debris are present in bed of atrophy, lesion can appear grey rather than black.