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. 2012 Dec 12;2012(12):CD005607. doi: 10.1002/14651858.CD005607.pub4

Linden 1990.

Methods Randomised controlled trial conducted in USA, number of centres unclear; patients initially divided into 4 groups based on surgical technique, and then further subdivided based on whether received antibiotics or not, to attain a total of 8 subgroups; study remained open until sufficient numbers were recruited and questionnaires returned
Grading of quality: 
 Randomisation = C 
 Blinding = D 
 Intention‐to‐treat analysis = C 
 Follow‐up = C
Overall quality grading = C
Participants 80 children (age range 13 months to 17 years (mean: 5 years)) undergoing tonsillectomy (indication not specified). Whether children undergoing adenotonsillectomy were included was not clear. Study and control group demographics and other characters not mentioned.
Exclusion criteria: not specified
Interventions No detail regarding the type of antibiotic or the method of administration given
Outcomes Primary outcome: analgesic consumption (mean subjective rating on a scale of 1 to 3)
Period of observation: 5 days
Notes Anaesthetic technique not mentioned as controlled. Surgical technique was quasi‐controlled: 4 different surgical and haemostatic techniques in equal numbers (electrocautery + electrocautery, dissection + electrocautery, dissection + ligature, laser + laser) were used between the study and control groups.
Follow‐up: follow‐up rate of the 40 patients recruited in each of the antibiotic and control groups unclear
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment (selection bias) Unclear risk B ‐ Unclear