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. 2024 Aug 31;21:214. doi: 10.1186/s12974-024-03206-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Microglial overexpression of LILRB4 protects against ischemia-induced brain damage. (A) Experimental Protocol (Qod[Every Other Day], i.p.[intraperitoneal injection]). (B) MNSS score, Foot-Fault test, and corner turning test after tMCAO. (n = 8; *p = 0.0320/0.0320/0.0294/0.0126/0.0250/0.0272/0.0260, Control-KO/TG IR vs. LILRB4-KO/TG IR). (C) The representative laser speckle images of Control, LILRB4-KO and LILRB4-TG mice before operation and 1,3 days after tMCAO. (D) The infarct-side perfusion volume changed in mice Control, LILRB4-KO and LILRB4-TG mice at 1 and 3 days after tMCAO 1 h. (n = 8; *p = 0.0332, Control-KO/TG IR vs. LILRB4-KO/TG IR). (E) Representative images of TTC staining of brain sections from Control and LILRB4-KO, LILRB4-TG mice. (F) Quantitation and statistical evaluation of (E). (n = 5; **p = 0.0026, *p = 0.0447)