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. 2024 Jun 19;25(3):308–318. doi: 10.1177/17511437241259437

Table 1.

Characteristics of included studies.

Author & year No of participants Mean age (±SD) Population Hyperoncotic albumin intervention Control Duration to last follow-up (days) Relevant outcomes
Annane 2013 2857 (1553 sepsis) Albumin: 63 (±19.3) a
Control: 62.7 (±18.6) a
Adults requiring fluid resuscitation Mixed colloids (including 20% albumin) for fluid therapy during ICU stay Crystalloid solutions for all fluid therapy 90 Mortality @ 28 days
Need for RRT
Days alive & free from organ support
Caironi 2014 1818 Albumin: 68 (±14.8) a
Control: 68.3 (±13.7) a
Adults with severe sepsis 300 ml 20% albumin followed by daily dosing titrated to serum level Crystalloid fluids 90 Mortality @ 28 days
Need for RRT & MV
Duration of shock
CFB @ 7 days
Charpentier 2011 798 65.7 (±15.6) a b Adults with septic shock 100 ml 20% albumin 8-hourly for 3 days 100 ml 0.9% saline 8-hourly for 3 days 28 Mortality @ 28 days
Duration of shock
Dolecek 2009 56 Albumin: 49 (±48.2) a
Control: 44 (±34.5) a
Adults with severe sepsis 100 ml 20% albumin 12-hourly for 3 days 250 ml 6% starch 6-hourly for 3 days 28 Mortality @ 28 days
Duration of MV
CFB @ 3 days
Maiwall 2022 100 Albumin: 50.1 (±9.87)
Control: 47.3 (±11.3)
Adults with cirrhosis and sepsis-induced hypotension 0.5–1.0 g/kg 20% albumin over 3 h 30 ml/kg of PlasmaLyte-148 solution over 3 h 28 Mortality @ 28 days
Need for RRT & MV
Duration of shock
CFB @ 24 h
Martensson 2018 321 (35 sepsis) Albumin: 65.9 (±11.7) a
Control: 64.3 (±12.5) a
Adults requiring fluid resuscitation 20% albumin for all fluid resuscitation for up to 48 h 4%–5% albumin for all fluid resuscitation for up to 48 h Hospital discharge CFB @ 48 h

RRT: renal replacement therapy; MV: mechanical ventilation; CFB: cumulative fluid balance.

a

Mean values mathematically derived from reported median.

b

Mean age reported for whole cohort only.

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