Table 1.
Author & year | No of participants | Mean age (±SD) | Population | Hyperoncotic albumin intervention | Control | Duration to last follow-up (days) | Relevant outcomes |
---|---|---|---|---|---|---|---|
Annane 2013 | 2857 (1553 sepsis) | Albumin: 63 (±19.3)
a
Control: 62.7 (±18.6) a |
Adults requiring fluid resuscitation | Mixed colloids (including 20% albumin) for fluid therapy during ICU stay | Crystalloid solutions for all fluid therapy | 90 | Mortality @ 28 days Need for RRT Days alive & free from organ support |
Caironi 2014 | 1818 | Albumin: 68 (±14.8)
a
Control: 68.3 (±13.7) a |
Adults with severe sepsis | 300 ml 20% albumin followed by daily dosing titrated to serum level | Crystalloid fluids | 90 | Mortality @ 28 days Need for RRT & MV Duration of shock CFB @ 7 days |
Charpentier 2011 | 798 | 65.7 (±15.6) a b | Adults with septic shock | 100 ml 20% albumin 8-hourly for 3 days | 100 ml 0.9% saline 8-hourly for 3 days | 28 | Mortality @ 28 days Duration of shock |
Dolecek 2009 | 56 | Albumin: 49 (±48.2)
a
Control: 44 (±34.5) a |
Adults with severe sepsis | 100 ml 20% albumin 12-hourly for 3 days | 250 ml 6% starch 6-hourly for 3 days | 28 | Mortality @ 28 days Duration of MV CFB @ 3 days |
Maiwall 2022 | 100 | Albumin: 50.1 (±9.87) Control: 47.3 (±11.3) |
Adults with cirrhosis and sepsis-induced hypotension | 0.5–1.0 g/kg 20% albumin over 3 h | 30 ml/kg of PlasmaLyte-148 solution over 3 h | 28 | Mortality @ 28 days Need for RRT & MV Duration of shock CFB @ 24 h |
Martensson 2018 | 321 (35 sepsis) | Albumin: 65.9 (±11.7)
a
Control: 64.3 (±12.5) a |
Adults requiring fluid resuscitation | 20% albumin for all fluid resuscitation for up to 48 h | 4%–5% albumin for all fluid resuscitation for up to 48 h | Hospital discharge | CFB @ 48 h |
RRT: renal replacement therapy; MV: mechanical ventilation; CFB: cumulative fluid balance.
Mean values mathematically derived from reported median.
Mean age reported for whole cohort only.