Table 4.

The pfama-1 codons predicted to underline natural selection in KP-Pakistan and global samples

Domain	Amino acid position	Episodic positive selection by MEME	Pervasive positive selection
			FEL	IFEL
Signal and prosequence	34a		*	*
	35		*
	52a		*	*
DI	167a	T-K	*	*
	172a	G-E	*	*
	187a		*	*
	197a	E-Q/G/D/R/H	*	*
	200a	H-D/L/R
	242a	D-Y	*	*
	267a		*	*
	283a	S-L	*	*
	300a		*
	308a	Q-E/K	*	*
DII	330a	P-S	*	*
	395	K-R	*	*
	404a	T-R	*
	405a		*
	435a	I-N/T	*	*
	439a	N-H/D	*	*
DIII	451a	M-K	*	*
	485a	K-I	*	*
	493a	D-A	*	*
	503a	R-N/H	*	*
Transmembrane and cytoplasmic	512a	R-K	*	*
	544a	K-N	*	*

^aPositions of amino acid changes that were commonly found in global pfama-1.