Table 1.
Demographic and clinical characteristics of AT patients.
| Patient ID | Sex | Ethnicity | AO (months) | AE (years) |
SARA | Wheelchair confined | Infections/Lung disease | Immunodeficiency | Autoimmunity | Cancer |
|---|---|---|---|---|---|---|---|---|---|---|
| AT1 | F | Non-Hispanic | 72 | 41 | 25 | Yes | No | HIGM | AIT | Gastric cancer |
| AT2 | M | Other | 26 | 14 | 22.5 | Yes | No | Low naive T cells, defective proliferative response | Antinuclear antibodies + | No |
| AT3 | M | Non-Hispanic | 12 | 21 | NA | Yes | Yes | Pan-hypogammaglobulinemia, low CD19+ | No | ALL |
| AT4 | F | North-African | 23 | 10 | 15.5 | No | No | sIgAD | Rheumatic fever | No |
| AT5 | F | Non-Hispanic | 60 | 11 | NA | No | Yes | Low IgG, IgA, naive T cells, defective proliferative response | No | No |
| AT6 | F | Non-Hispanic | 72 | 43 | 32 | No | No | HIGM, low IgG, IgA | AIT | No |
| AT7 | F | Non-Hispanic | 24 | 21 | 24 | Yes | Yes | Low CD3+, CD4+, CD8+, HIGM | No | No |
| AT8 | F | Non-Hispanic | 72 | 11 | 16 | No | Yes | Low naive T cells, defective proliferative response | No | No |
| AT9 | F | Non-Hispanic | 12 | 8 | NA | No | Yes | Low IgG, IgA, CD3+, CD4+, CD8+ T cells, defective proliferative response | No | Burkitt lymphoma |
| AT10 | F | Non-Hispanic | 12 | 6 | NA | No | Yes | Low IgG, IgA, CD3+, CD4+ T cells, defective proliferative response | No | No |
| AT11 | F | Non-Hispanic | 18 | 24 | 22 | Yes | No | Low CD3+, CD4+, CD8+, naive T cells, IgA, defective proliferative response | No | No |
| AT12 | M | Non-Hispanic | 19 | 18 | 24 | Yes | Yes | Low CD3+, CD4+, CD8+, naive T cells, IgA, defective proliferative response | AIT | No |
| AT13 | F | Non-Hispanic | 7 | 9 | 16 | No | No | sIgAD | No | No |
| AT14 | M | Non-Hispanic | 1 | 20 | 22 | Yes | No | Low CD4+, CD8+ naive T cells, defective proliferative response | No | No |
| AT15 | F | Non-Hispanic | 21 | 12 | NA | No | Yes | Low CD8+, low IgA | No | No |
| AT16 | M | Non-Hispanic | 9 | 18 | NA | No | Yes | Low CD3+, CD4+, CD8+, IgG, HIGM | Psoriasis | No |
| AT17 | M | North-African | 12 | 15 | 16 | No | No | Low IgG, IgA | No | No |
| ATF A | M | Non-Hispanic | 24 | 15 | NA | Yes | No | Low CD4+, pan-hypogammaglobulinemia | No | No |
| ATF B | M | Non-Hispanic | 12 | 18 | NA | Yes | Yes | Low CD8+ | No | No |
| ATF C | M | Non-Hispanic | 24 | 18 | NA | Yes | No | No | No | No |
AO, age at onset; AE, age at enrollment; SARA, Scale for Assessment and Rating of Ataxia; HIGM, high IgM; AIT, autoimmune thyroiditis; ALL, acute lymphoblastic leukemia; sIgAD, selective IgA deficiency; NA, not available.