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. 2024 Aug 19;15:1396777. doi: 10.3389/fimmu.2024.1396777

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Copyright © 2024 Boersma, Puddinu, Huard, Fauteux-Daniel, Wirapati, Guedri, Tille, McKee, Pittet, Palmer and Bourquin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Systemic IL-6 levels 3h and 24h after R848 (10 μg, s.c.) or PBS injection in Gsdmd-/- and WT mice (n=4 per group). (B-D) Cxcl10 (B), Ifng (C) and Tnfa (D) gene expression in the lymph nodes (LN) and spleen (SP) after 3h of R848 or PBS treatment. (E, F) Cell surface CD44, CD69, MHC-I and CD62L levels on CD4⁺ (E) and CD8⁺ (F) T cells (CD3⁺) from the lymph nodes after 3h of R848 treatment. (G) Cell surface CD83, CD86, MHC-II and CD80 levels on macrophages (CD11b⁺, F4/80⁺) from the spleen (SP) after 3h of R848 treatment. ELISA graphs represent one experiment and each dot represent 1 mouse. In the qPCR data each dot represents the mean of a technical triplicate of each mouse.