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. 2024 Jul 31;27(9):110526. doi: 10.1016/j.isci.2024.110526

Figure 8.

Figure 8

RSG attenuates cartilage degeneration in vivo

(A) Schematic diagram illustrating the experimental design with animals. This figure was created using Figdraw (https://www.figdraw.com/static/index.html#/).

(B) Three-dimensional sagittal and coronal images of mouse knee joints reconstructed using micro-CT, with the red arrow indicating osteophyte formation (scale bar = 1 mm).

(C) Histological assessments, including H&E, TB, and SOFG staining, of knee sections from each group (scale bar = 200 μm).

(D) Quantification of articular osteophytes in each group (n = 8 per group).

(E) Quantitative analysis of osteophyte maturity in each group (n = 8 per group). (F) OARSI scores for the six groups of mice (n = 8 per group).

(G) Modified Mankin scores for each group (n = 8 per group).

(H) Measurement of cartilage thickness in knee joints among the six groups (n = 8 per group). Two-tailed p values were calculated, and statistical significance was defined as p < 0.05, denoted as 'ns' for no statistical difference, and indicated as ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. All experiments and images shown are representative.