Table 3.

Summary of in vitro and in vivo studies evaluating therapeutic failures (either lack of efficacy or established resistance) against Psoroptes ovis in sheep and cattle.

Host	Country	Macrocyclic lactone	Type of study	Reference
SHEEP	United Kingdom	Moxidectin	In vitro -Resistance confirmed	Doherty et al. (2018)
		Ivermectin Doramectin Moxidectin	In vitro -Resistance confirmed	Sturgess-Osborne et al. (2019)
	Argentina	Ivermectin	In vivo -Lack of efficacy	Larroza et al. (2020a)
			In vitro -Resistance confirmed	Soler et al. (2022)
CATTLE	Belgium	Ivermectin	In vivo -Lack of efficacy	Lekimme et al. (2010)
		Ivermectin Doramectin Moxidectin	In vivo -Lack of efficacy	Van Mol et al. (2020)
	Argentina	Ivermectin	In vivo -Lack of efficacy	Lifschitz et al. (2018)
		Ivermectin Doramectin	In vivo -Lack of efficacy	Canton et al. (2023)