Table 1. Study sites with annual number of eligible patients based on 2019 ICU volume.

Trauma centre	Location	Patients meeting study eligibility criteria	Stratification for randomisation
Harborview Medical Center (University of Washington)	Seattle, WA, USA	702	Very high
University of Alabama at Birmingham	Birmingham, AL, USA	615	Very high
Grady Memorial Hospital (Morehouse School of Medicine)	Atlanta, GA, USA	583	Very high
Lehigh Valley Health Network	Allentown, PA, USA	507	Very high
Rhode Island Hospital	Providence, RI, USA	504	High
Shock Trauma (University of Maryland Medical Center)	Baltimore, MD, USA	398	High
Froedtert Hospital (Medical College of Wisconsin)	Milwaukee, WI, USA	321	High
UC Davis Medical Center	Sacramento, CA, USA	289	High

ALAlabamaCACaliforniaGAGeorgiaICUintensive care unitMDMarylandPAPennsylvaniaRIRhode IslandWAWashingtonWIWisconsin