Figure 5.

Mucosal boosting induces a highly correlated network of FcγR-binding antibodies and effector functions in the BAL

(A) Correlation heatmaps were generated for FcγR-binding antibodies and effector-mediated functions at week 15 for the antigens used in this study for NHPs who received no boost. Callout boxes for the antigens used for the specific assays (FcγR-binding, ADCP, ADNP, ADCD, and ADNKA) and their orders are shown.

(B) Same as (A), but for NHPs at week 15 that received an IM boost.

(C) Same as (A), but for NHPs at week 15 that received an IN boost.

(D) Same as (A), but for NHPs at week 15 that received a mucosal boost. Heatmap legend for the correlation coefficient is shown in the bottom right.