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. Author manuscript; available in PMC: 2024 Sep 2.
Published in final edited form as: FASEB J. 2022 Jan;36(1):e22077. doi: 10.1096/fj.202101086R

FIGURE 8.

FIGURE 8

MYC expression is downregulated in endothelial cells from human cirrhotic livers. (A) An integrated t-stochastic neighbor embedding (tSNE) plot of the GSE136103 dataset, showing cell type specific clusters of uninjured and cirrhotic livers (n = 5). Endothelial cluster in light blue is outlined. Inset shows the sample split based on sex. (B) tSNE plots showing the expression of classical endothelial markers PECAM1 and VWF to be high in the endothelial cluster. (C) Violin plots showing normalized RNA expression of MYC across all cell types separated based on sex in both uninjured and cirrhotic non-parenchymal liver cells. (D) Violin plots showing normalized RNA expression of MYC between uninjured and cirrhotic endothelial cells. A total of 66 135 cells are shown across 12 clusters. ILCs, innate lymphoid cells; MPs, mononuclear phagocytes; pDCs, plasmacytoid dendritic cells