TABLE 1.
Genes exclusively altered in EC-Myc KO liver by short-term HFD exposure and their association with inflammation, fibrosis, and hepatocellular carcinoma
| Gene | Male |
Female |
Function |
||||
|---|---|---|---|---|---|---|---|
| Fold change | p value | Fold change | p value | Inflammation | Fibrosis | HCC | |
| Mmp13 | 4.78 | 8.96E-04 | 6.87 | 1.09E-03 | √ | ||
| Cd14 | 3.34 | 3.83E-08 | 1.81 | 5.94E-03 | √ | ||
| Gna15 | 2.94 | 1.23E-04 | 2.74 | 2.44E-03 | √ | ||
| Dlgap5 | 2.90 | 7.90E-04 | 3.02 | 3.40E-03 | √ | ||
| Plau | 2.89 | 2.48E-05 | 3.02 | 2.04E-05 | √ | √ | √ |
| Kif23 | 2.76 | 1.15E-05 | 2.16 | 3.83E-03 | √ | ||
| Col3a1 | 2.64 | 8.08E-04 | 1.70 | 4.57E-03 | √ | √ | |
| Col1a1 | 2.58 | 5.30E-03 | 1.88 | 7.72E-03 | √ | ||
| Kif20b | 2.50 | 1.22E-04 | 3.38 | 2.58E-04 | √ | ||
| Kifc1 | 2.46 | 1.45E-03 | 3.58 | 1.01E-03 | √ | ||
| Vcan | 2.41 | 3.96E-03 | 2.92 | 4.47E-03 | √ | ||
| Clec1b | 2.28 | 3.33E-18 | 1.87 | 2.50E-03 | √ | ||
| Ube2c | 2.20 | 7.18E-04 | 3.43 | 6.28E-04 | √ | ||
| S100a4 | 2.19 | 5.65E-03 | 2.74 | 5.06E-04 | √ | √ | |
| Cxcl14 | 2.12 | 5.23E-04 | 2.03 | 6.08E-03 | √ | ||
| Rad54l | 2.10 | 3.80E-03 | 1.85 | 8.95E-03 | √ | ||
| Tmem176a | 1.90 | 2.12E-12 | 1.54 | 1.15E-03 | √ | ||
| Gdpd1 | 1.87 | 5.57E-04 | 1.85 | 3.36E-03 | √ | ||
| Vim | 1.83 | 5.34E-05 | 1.51 | 6.74E-03 | √ | ||
| Anxa3 | 1.82 | 3.42E-06 | 1.77 | 1.79E-03 | √ | ||
| Col1a2 | 1.81 | 9.27E-03 | 1.57 | 9.75E-03 | √ | ||
| Anxa5 | 1.77 | 1.18E-05 | 1.52 | 7.25E-04 | √ | ||
| Aspm | 1.75 | 6.16E-03 | 2.23 | 5.56E-03 | √ | ||
| Ccdc80 | 1.74 | 4.05E-04 | 1.59 | 2.00E-04 | √ | ||
| Cd38 | 1.73 | 1.31E-11 | 1.64 | 3.58E-03 | √ | √ | |
| Ccl21a | 1.61 | 2.04E-02 | 2.19 | 6.75E-03 | √ | √ | |
| Nusap1 | 1.54 | 1.15E-02 | 2.39 | 2.29E-03 | √ | ||
| Klf13 | −1.53 | 6.01E-05 | −1.56 | 1.25E-04 | √ | ||
| Scap | −1.53 | 3.50E-07 | −1.64 | 5.72E-04 | √ | ||
| Hpd | −1.55 | 6.00E-05 | −2.08 | 9.28E-06 | √ | ||
| Cebpb | −1.56 | 4.18E-04 | −1.55 | 2.76E-04 | √ | ||
| Ceacam1 | −1.58 | 4.32E-15 | −1.54 | 2.93E-08 | √ | ||
| Fbp1 | −1.59 | 5.99E-06 | −2.01 | 4.22E-06 | √ | ||
| Acsm3 | −1.62 | 2.29E-10 | −1.52 | 1.72E-03 | √ | ||
| Fpgs | −1.65 | 2.71E-10 | −1.61 | 7.27E-05 | √ | ||
| Pfkfb2 | −1.66 | 5.94E-05 | −1.51 | 4.29E-03 | √ | ||
| Fgf1 | −1.70 | 7.62E-10 | −1.89 | 8.84E-08 | √ | ||
| Glul | −1.74 | 2.26E-06 | −2.13 | 7.67E-12 | √ | ||
| Pck1 | −1.92 | 7.39E-07 | −1.95 | 7.42E-08 | √ | ||
| Ar | −2.08 | 1.73E-03 | −2.44 | 2.69E-04 | √ | ||
| Egfr | −2.19 | 9.19E-08 | −1.96 | 8.72E-05 | √ | √ | |
| Il6ra | −2.23 | 9.81E-05 | −2.57 | 1.68E-12 | √ | ||
| Pim3 | −2.31 | 5.11E-07 | −1.63 | 1.46E-04 | √ | ||
Note: Results represent fold changes relative to CTD group. Genes exclusively altered in both EC-Myc KO male (n = 4) and female (n = 3) animals are shown. Abbreviations: CTD, low-fat control diet; EC-Myc KO, endothelial c-Myc knockout; HCC, hepatocellular carcinoma; HFD, high-fat diet.