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| Compounds | CC50 (mg mL−1) | SARS-CoV-2 | MERS-CoV | HCoV-229E | |||
|---|---|---|---|---|---|---|---|
| IC50 (mg mL−1) | SI | IC50 (mg mL−1) | SI | IC50 (mg mL−1) | SI | ||
| Hydrazide (Hyd) | 0.4913 | 0.054 | 9.09 | 0.23 | 2.1 | 0.0277 | 17.7 |
| Hydrazone (HQ) | 0.805 | 0.052 | 15.5 | 0.302 | 2.7 | 0.134 | 6.0 |
| Pyrrolone (15A) | 65.362 | 0.158 | 413 | 0.0516 | 1266 | 0.0447 | 1462 |
