Fig. 2.

Signaling pathways involved in TNFR2. TNFR2 recruits TRAF2 and cIAP1/2 to activate NF-κB and AP1 transcription factors via distinct pathways, resulting in the transcription of target genes. This, in turn, promotes the development of tumor cells and angiogenesis. Moreover, TNFR2 can engage in crosstalk with TNFR1 to induce apoptosis