Fig. 5.

Correlations between LPS-induced CXCL10 levels in male C57BL/6J mouse brains and anxiety-like behavior. Micro-osmotic pumps containing saline or β-FNA (42 μg/d) were surgically implanted and delivered at a flow rate of 0.5 μL/h for 7d. 6d post-surgery, mice (n = 7–8/group) were injected (i.p.) with either 25 μL saline control or LPS (0.83 mg/kg). Behavioral tests were administered 24 h later, and termination followed immediately after. A CCL2 and (B) CXCL10 were measured via ELISA in brain region and spleen homogenates. Data are presented as mean ± SEM. Linear regression analysis was used to assess frontal cortex, hippocampus, and spleen CCL2 and CXCL10 levels with EPM-time spent in closed arms. Linear regression statistics and symbols are provided in the figure, and only significant results are shown