Fig. 8.

Correlations between LPS-induced chemokines in male C57BL/6J tissues and latency to immobility in the FST. Micro-osmotic pumps containing saline or β-FNA (42 μg/d) were surgically implanted and dispensed at a flow rate of 0.5 μL/h for 7d. 6d post-surgery, mice (n = 7–8/group) were injected (i.p.) with either 25 μL saline control or LPS (0.83 mg/kg). Behavioral tests were administered 24 h later, and termination followed immediately after. A CCL2 and (B) CXCL10 were measured via ELISA in brain region and spleen homogenates. Data are presented as mean ± SEM. Linear regression analysis was used to assess frontal cortex, hippocampus, and spleen CCL2 and CXCL10 levels with percentage of time spent immobile and latency to immobility in the FST. Linear regression statistics and symbols are provided in the figure, and only significant results are shown