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. 2024 Sep 1;21:215. doi: 10.1186/s12974-024-03208-2

Fig. 2.

Fig. 2

A feed-forward reciprocal relationship between glutamate excitotoxicity and TRAIL. (A) Representative images of HEBSCs treated with glutamate (3mM) +/- αTRAIL monoclonal antibodies for 24 h. (B) Glutamate (3mM) caused robust increases in PI uptake in dentate gyrus and CA regions that was blocked by αTRAIL in a concentration-dependent manner. F4,44=7.328, p = 0.0001, ****p < 0.0001 vs. control, ††p < 0.01, †††p < 0.001 vs. Glutamate 3mM + 0 µg/mL αTRAIL, Sidak’s multiple comparison test. N = 9–10 slices/group (C) Representative images of HEBSCs treated with recombinant TRAIL +/- MK801. (D) TRAIL caused a concentration-dependent increase in neurotoxicity in dentate gyrus and CA regions that was prevented by MK801. F4,38 = 26.4, p < 0.0001. ****p < 0.0001, Sidak’s multiple comparison test. N = 8–10 slices/group