Fig. 6.

T-cell Clusters Associated with PFF-induced Neuroinflammation and the Influence of AZD1480 Treatment. (A) Unsupervised clustering of scRNA-Seq data and UMAP plot of all T-cells (T) from CD45⁺ mononuclear cells sorted from the midbrain of Line 61 mice after monomer, PFF + VH, or PFF + AZD1480 injection. (B) Cell numbers of the five T-cell clusters analyzed by scRNA-Seq. C. Dot plot of conserved marker genes in the five T-cell clusters across groups. D. Violin plots show the genes restored by AZD1480 treatment in the T3 cluster across groups. E. Violin plots showing genes restored by AZD1480 treatment in the T1 and T5 clusters across groups