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. 2024 Mar 22;120(10):1155–1163. doi: 10.1093/cvr/cvae062

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© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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α- and β-diversity metrics of all samples (n = 538), categorized according to intestinal region (A and B) and sequencing batch (C and D). (A and C) Shannon index, an α-diversity metric. (B and D) Bray–Curtis index (β-diversity metric). Significance of Shannon index (P < 0.05) determined using Mann–Whitney U (two comparison groups) or Kruskal–Wallis (more than two comparison groups) tests. Significance of Bray–Curtis index determined using PERMANOVA with adjustment for multiple comparisons (q < 0.05).