TABLE 4.

Observational studies for nuclear medicine applications in haemorrhagic stroke diagnosis.

NCT Number	Study Title	Conditions	Interventions	Primary/Secondary Outcome Measures	Enrollment/ Age	Study Design	Location
NCT 01829386 (65)	Non-heme iron load quantification in the brain MRI of patients with stroke	Haemorrhagic stroke	MRI scan with non-heme iron levels	• Create a non-invasive imaging modality of iron levels assessments for brain damage estimation • Validated quantification within 30 days	34 adults including older adults	Cohort, time prospective	United States
NCT 02033291 (59)	Blood-brain barrier quantification in cerebral small vessel disease	Cortical stroke with cerebral hamorrhage	Dynamic contrast enhanced brain MRI	• Pharmacokinetic parameter values evaluated as a function of scan duration to obtain the shortest scan duration without compromising the reliability of blood brain barrier permeability • Quantification ki and vb outcome measures to determine the reproducibility of dynamic contrast enhanced MRI method (within day 1 and 2, and 4 weeks)	17 adults including older adults	Case-only, time prospective	Netherland
NCT 06213870 (66)	Screening of endovascular thrombectomy with MRI in acute ischemic stroke	Symptomatic intracranial hamorrhage	Fluid-attenuated inversion recovery sequence vascular hyperintensity-diffusion-weighted MRI image mismatch preoperative and post-endovascular thrombectomy	• Predict the consistency between MRI and perfusion examination in determining endovascular thrombectomy indications and functional independence rate, National institutes of health stroke scale (NIHSS) > 4 scores, modified Rankin scale 0–2 scores at 90 days	309 adults including older adults	Cohort, time retrospective	China
Chibbaro et al. (67) NCT 01113645	Impact of cranioplasty on cerebral perfusion	Decompressive craniectomy post head injuries, subarachnoid hamorrhage, intra-cerebral hamorrhage, cerebral thrombosis, infarction, malignant middle cerebral artery	Cerebral CT perfusion and trans-cranial doppler evaluations	• Evaluate the impacts of local and global cerebral hemodynamic and blood flow outcomes as prognostic factors, by Glasgow outcome score, frontal assessment battery, and mini mental state examination scores, within 1 week prior and 6 and 24 weeks post-cranioplasty	20 adults including older adults	Cohort, time prospective	France
NCT 04554368 (68)	A novel score to predict risk of symptomatic intracerebral hamorrhage	Intracerebral hamorrhage post-stroke thrombectomy	Intra-arterial contrast (Henan-PRIHS) enhanced flat detector CT	• Predicting the stratification risk of symptomatic intracranial hamorrhage scores in affected hemisphere within 5 days	300 adults including older adults	Patient registry, case-only, time prospective	China