Figure 6.

Expression of p44/42 MAPK in B6C3F1/N mouse lung. In normal mouse lungs, p44/42 MAPK expression is predominantly in the endothelium (arrows) and a few transmigrating leukocytes (arrowheads) (A, B). However, the neoplastic alveolar/bronchiolar cells stain positive for p44/42 MAPK in the mouse lung tumors. The distribution pattern of p44/42 MAPK expression in neoplastic cells was predominantly nuclear and mainly in neoplastic cells at the periphery of the neoplasm and those infiltrating surrounding parenchyma (C).