Table 1.

Incidences of Alveolar/Bronchiolar Tumors in Rats in the 2-Year Inhalation Study of Antimony Trioxide (NTP TR 590).^#

	Chamber Control	3 mg/m3	10 mg/m3	30 mg/m3
Males
Alveolar/bronchiolar adenomas, multiple
	0	1	0	3
Alveolar/bronchiolar adenomas (including multiples)a,b
	3/50 (6%)	4/50 (8%)	6/50 (12%)	8/50 (16%)
Poly-3 test*	P=0.057	P=0.478	P=0.253	P=0.083
Alveolar/bronchiolar carcinomasc
	0/50 (0%)	0/50 (0%)	2/50 (4%)	0/50 (0%)
Poly-3 test*	P=0.702N	--	P=0.245	--
Alveolar/bronchiolar adenomas and carcinomas (combined)d
	3/50 (6%)	4/50 (8%)	8/50 (16%)	8/50 (16%)
Poly-3 test*	P=0.067	P=0.478	P=0.104	P=0.083
Females
Alveolar/bronchiolar adenomas, multiple
	0	0	1	0
Alveolar/bronchiolar adenomas (including multiples)e
	0/50 (0%)	2/50 (50%)	6/50 (12%)	5/50 (10%)
Poly-3 test*	P=0.029	P=0.235	P=0.012	P=0.021
Alveolar/bronchiolar carcinomas
	0/50 (0%)	0/50 (0%)	0/50 (0%)	0/50 (0%)
Alveolar/bronchiolar adenomas and carcinomas (combined)
	0/50 (0%)	2/50 (4%)	6/50 (12%)	5/50 (10%)
Poly-3 test*	P=0.029	P=0.235	P=0.012	P=0.021

^*P value listed under chamber control is associated with the trend test. P values listed under each exposed group correspond to pairwise comparisons between the chamber controls and that exposed group. The Poly-3 test accounts for differential mortality in animals that do not reach terminal kill. A negative trend is indicated by N.

^aHistorical incidence for 2-year inhalation studies with chamber control groups (mean ± standard deviation): 4/150

^bNumber of animals with neoplasm per number of animals with lung examined microscopically.

^cHistorical incidence for inhalation studies: 0/150; all routes: 0/299.

^dHistorical incidence for 2-year inhalation studies with chamber control groups (mean ± standard deviation): 4/150

(2.7% ± 3.1%), range 0%–6%; all routes: 4/299 (1.3% ± 2.4%), range 0%–6%.

(2.7% ± 3.1%), range 0%–6%; all routes: 4/299 (1.3% ± 2.4%), range 0%–6%.

^eHistorical incidence for inhalation studies: 0/150; all routes: 0/300.

^#Table #9 from the NTP Technical Report on the Toxicology and Carcinogenesis Studies of Antimony Trioxide (Technical Report 590)