Table 3.
Summary of Kras and Egfr Mutations in Nontumor Lung Tissue and Alveolar/bronchiolar Adenomas and Carcinomas from Wistar Han Rats in the 2-Year Inhalation Study of Antimony Trioxidea
| Tissue: | Antimony Trioxide | Mutation Frequencyb |
Kras Codons |
Egfr Exons |
||||
|---|---|---|---|---|---|---|---|---|
| Concentration | Kras | Egfr | 16 | 18 | 19 | 20 | 21 | |
|
| ||||||||
| Nontumor lung: | 0 mg/m3 | 0/11 (0) | 0/11(0) | 0 | 0 | 0 | 0 | 0 |
| Lung tumors: | 0 mg/m3 | 0/4 (0) | 0/4 (0) | 0 | 0 | 0 | 0 | 0 |
| 3 mg/m3 | 0/5 (0) | 3c/5 (60) | 0 | 2 | 2 | 0 | 1 | |
| 10 mg/m3 | 1/11 (9) | 6/11 (55) | 1 | 2 | 2 | 1 | 1 | |
| 30 mg/m3 | 0/10 (0) | 4/10 (40) | 0 | 0 | 1 | 2 | 1 | |
|
| ||||||||
| All exposed groups combined | 1/26 (4) | 13c/26 (50) | 1 | 4 | 5 | 3 | 3 | |
| Without pulmonary overload | 0/5 (0) | 3c/5 (60) | 0 | 2 | 2 | 0 | 1 | |
| With pulmonary overload | 1/21 (5) | 10/21 (48) | 1 | 2 | 3 | 3 | 2 | |
a
Male and female Wistar Han rats were exposed to 0, 3, 10, or 30 mg/m3 antimony trioxide daily by inhalation for 2 years. Silent mutations are not included. There were no significant differences from the chamber control group by the one-sided Fisher’s exact test and no significant exposure-concentration trend by the Cochran-Armitage trend test.
b
Number of tissues with mutation/number of tissues assayed (% with mutation).
c
Same animal with double mutations (M246 with Egfr 19 and 21; M257 with Egfr 18 and 19).