TABLE 8.
Illumina BaseSpace™ Correlation Engine generated top canonical pathways common to alveolar/bronchiolar carcinomas (ABCs) from B6C3F1/N mice exposed to Antimony trioxide (CMD) for 2 years and human non-small cell lung cancer as predicted by Broad Institute’s Molecular Signatures Database (MSigDB) using the respective transcriptomic data.
| Top 20 concordant canonical pathways in mouse CMD-exposed ABCs and human NSCLC | Bioset Score | Mouse, −log(p value) | Common genes | Human, −log(p value) | Common genes |
|---|---|---|---|---|---|
|
| |||||
| Nop56p-associated pre-rRNA complex | 93 | 40.24 | 76 | 0.04 | 18 |
| 60S ribosomal subunit, cytoplasmic | 68 | 29.60 | 42 | 0.04 | 8 |
| 55S ribosome, mitochondrial | 56 | 24.15 | 52 | 17.64 | 49 |
| 40S ribosomal subunit, cytoplasmic | 49 | 21.32 | 29 | 0.03 | 3 |
| Oxidative phosphorylation | 48 | 20.85 | 60 | 8.59 | 52 |
| Huntington’s disease | 43 | 18.49 | 72 | 4.47 | 70 |
| Focal adhesion | 40 | 17.38 | 65 | 26.64 | 97 |
| Vascular smooth muscle contraction | 38 | 16.40 | 45 | 20.29 | 61 |
| Parkinson’s disease | 35 | 15.36 | 52 | 5.46 | 47 |
| 39S ribosomal subunit, mitochondrial | 35 | 15.12 | 32 | 9.89 | 29 |
| Validated targets of C-MYC transcriptional activation | 35 | 15.07 | 41 | 12.08 | 41 |
| Cytokine-cytokine receptor interaction | 34 | 14.96 | 63 | 19.66 | 91 |
| Hematopoietic cell lineage | 34 | 14.74 | 33 | 12.43 | 42 |
| Pyrimidine metabolism | 29 | 12.74 | 42 | 13.62 | 49 |
| Alzheimer’s disease | 27 | 11.89 | 60 | 3.30 | 58 |
| Chemokine signaling pathway | 25 | 10.74 | 49 | 19.41 | 83 |
| Purine metabolism | 24 | 10.54 | 53 | 11.00 | 64 |
| LPA receptor mediated events | 24 | 10.48 | 27 | 8.92 | 31 |
| DNA replication | 23 | 10.10 | 21 | 11.30 | 25 |
| 28S ribosomal subunit, mitochondrial | 23 | 9.77 | 20 | 8.74 | 20 |