Figure 2.

MYBL2 expression and activity is enriched in human NEPC and NE-like mouse models. A, Venn diagram integrating the differential gene expression (DEG) list from PBCre4:Ptenf/f (SKO) vs. PBCre4:Ptenf/f:Rb1f/f (DKO) mouse models, human NEPC vs. adenocarcinoma samples, and patient-derived xenografts of LuCaP obtained from human patients with NEPC vs. patients with adenocarcinoma shows that the three independent datasets shared 1,516 genes (left). GSEA of the 1,516 shared genes indicates that the fischer_dream_targets genes may be involved in the regulation of CRPC-AI development (right). All the pathways listed are statistically significant with P < 0.05. B, Bar and box plot summarizing the MYBL2 expression level in human patients with prostate cancer at different stages of the disease progression. C, Correlation analysis mouse and (D) human samples indicate that enrichment of MYBL2 transcriptional function is highly associated with NE and ESC gene signatures in NEPC models and patient samples compared with their adenocarcinoma counterparts. WT, wild type.