Table 2: Drug therapy proposal according to each TMJ OA stage.

Phenotype	Oral drugs	Intra-articular injection
Adaptive	x	X
Cartilage erosive	Glucosamine + Chondroitin	Hyaluronic acid
Bone erosion	x	I-PRF
Secondary inflammation	Undenatured Type II Collagen	Hyaluronic acid
Primary effusion	NSAIDs	Corticosteroids

I-PRF = injectable platelet rich fibrin; NSAIDs =Non-steroidal anti-inflammatory drugs.