Table 1: Description of the selected studies about genetic polymorphisms associated to EARR.
| Authors/Year/ Area of dental research |
Genes (SNP) evaluated | Polymorphism Association with EARR | |
|---|---|---|---|
| Yes | No | ||
| *Sharab et al.
2
(2015) Orthodontics |
P2RX7 (rs208294, rs1718119, rs2230912) CASP1/ICE (rs580253, rs554344, rs530537 IL1-B (rs1143634) IL1-A (rs1800587) IL1RA (rs41959) |
P2RX7 (rs208294) | P2RX7 (rs1718119, rs2230912) CASP1/ICE (rs580253, rs554344, rs530537 IL1-B (rs1143634) IL1-A (rs1800587) IL1RA (rs41959) |
| *Al-Qawasmi et al.
5
(2003) Orthodontics |
IL1-A (rs1143634) IL1-B (rs1143627) |
IL1-B (rs1143627) | IL1-A (rs1143634) |
| *Bastos Lages et al.
6
(2009) Orthodontics |
IL-1B (rs1143634) | IL-1B (rs1143634) | ______ |
| *Linhartova et al.
7
(2013) Orthodontics |
IL1A (rs16347) IL1B (rs1143627) IL1RN (rs9005) |
IL1A (rs16347) IL1B (rs1143627) IL1RN (rs9005)/Short alleles |
IL1B (rs1143627) IL1RN (rs9005)/Long alleles |
| *Iglesias-Linares et al.
8
(2012) Endodontics |
IL1A(rs1800587) IL1B (rs1143634) |
IL1B (rs1143634) | IL1 (rs1800587) |
| *Guo et al.
9
(2016) Orthodontics |
IL-6 (rs1800796) IL1RN (rs419598) |
IL-6 (rs1800796) | IL1RN (rs419598) |
| Borges de Castilhos et al.
10
(2019) Orthodontics |
RANKL (rs1038434, rs3742257, rs931273, rs12585229) RANK (rs12455775) OPG (rs2875845, rs3102724, rs1032128, rs3102728) |
RANK (rs12455775) OPG (rs2875845, rs3102724, rs1032128, rs3102728) |
RANKL (rs1038434, rs3742257, rs931273, rs12585229) |
| *Iglesias-Linares et al.
12
(2012) Orthodontics |
IL1A (rs1800587) IL1B (rs1143634) IL1RN (rs419598) |
IL1B (rs1143634) IL1RN (rs419598) |
IL1A (rs1800587) |
| *Tomoyasu et al.
17
(2009) Orthodontics |
IL-1B (rs1143634) | ______ | IL-1B (rs1143634) |
| *Pereira et al.
18
(2014) Orthodontics |
OPG (rs3102735) RANK (rs1805034) IL-1B (rs1143634) P2RX7 (rs1718119) |
P2RX7 (rs1718119) | OPG (rs3102735) RANK (rs1805034) IL-1B (rs1143634) |
| *Borilova Linhartova et al.
19
(2017) Orthodontics |
IL17A (rs2275913) P2RX7 (rs208294, rs1718119) SSP 1(rs9138, rs11730582) OPG (rs2073618, rs3102735) |
P2RX7 (rs208294, rs1718119) | PPS 1 (rs9138, rs11730582) OPG (rs2073618, rs3102735) |
| *Fontana et al.
20
(2012) Orthodontics |
Vitamin D receptor TaqI | Vitamin D receptor TaqI | ______ |
| *Iglesias-Linares et al.
21
(2014) Orthodontics |
OPG (rs9138, rs11730582) | OPG (rs9138, rs11730582) | ______ |
| Urban and Mincik
22
(2010) Endodontics |
IL-1A IL-1B IL1RN |
IL-1B | IL-1A IL1RN |
| **Lee et al.
25
(2022) Orthodontics |
SPP1 (rs 4754, rs1126616, rs9138) SFRP2 (rs3810765) |
SPP1 (rs9138) SFRP2 (rs3810765) |
SPP1 (rs 4754,rs1126616) |
| *Rutsch et al.
26
(2015) other areas of dental research |
MDA5 IFIH1 |
MDA5 IFIH1 |
______ |
| *Al-Qawasmi et al.
27
(2003) Orthodontics |
RANK (rs1805034) TNSALP (rs1256328) TNF-a (rs1799724) |
RANK (rs1805034) | TNF-a (rs1799724) TNSALP (rs1256328) |
| *Gülden et al.
28
(2009) Orthodontics |
IL1-A (-889) IL1-B (+3954) (rs1143634) |
IL1-A (-889) IL1-B (+3954) |
IL-1B (rs1143634) |
| *Iglesias-Linares et al.
29
(2017) Orthodontics |
IL1-B (rs1143634) IL1RN (rs419598) SPP1 (rs9138, rs11730582) |
IL1RN (rs419598) | IL1B (rs1143634) SPP1 (rs9138, rs11730582) |
| *Pettersson et al.
30
(2017) Other areas of dental research |
MDA5 IFIH1 |
MDA5 IFIH1 |
______ |
| Pereira et al.
31
(2016) Orthodontics |
IL1B (rs1143634) IL1RN (rs315952) IRAK1 (rs1059703) |
IRAK1 (rs1059703) | IL1B (rs1143634) IL1RN (rs315952) |
| Bastos et al.
32
(2015) Other areas of dental research |
IL1A (rs 180058) IL1B (rs1143634) IL1RN (rs419598) |
______ | IL1A (rs 180058) IL1B (rs1143634) IL1RN (rs419598) |
| Ciurla et al.
33
(2021) Orthodontics |
IL-1B (rs1143634) TNFRSF11B (rs3102735) CASP1(rs530537) IL-6 (rs1800796) |
IL-1B (rs1143634) | TNFRSF11B (rs3102735) CASP1(rs530537) IL-6 (rs1800796) |
| Roskamp et al.
34
(2017) Endodontics |
IL4 (rs2227284, rs2243268) | ______ | IL4 (rs2227284, rs2243268) |
| Roskamp et al.
35
(2018) Endodontics |
IL4 (rs2227284, rs2243268) | ______ | IL4(rs2227284, rs2243268) |
| Behnaz et al.
36
(2020) Orthodontics |
IL-1A (rs1800587) IL-1B (rs1143634) |
IL-1B (rs1143634) | IL-1A (rs1800587) |
| Ciurla et al.
37
(2021) Orthodontics |
P2RX7 (rs208294) IL1RN (rs419598) |
P2RX7 (rs208294) IL1RN (rs419598) |
______ |
| Iber-díaz et al.
38
(2020) Orthodontics |
Multiple putative loci and genes located at somatic chromosomes 2, 4, 8, 12, 18, and at sexual chromosomes X and Y | STAG (rs151184635) RP1-30E17.2 (rs55839915) SSP1 (rs11730582) P2RX7 (rs1718119) TNFRSF11A (rs8086340) |
Other loci and genes located on somatic chromosomes 2, 4, 8, 12, 18 and on sex chromosomes X and Y analyzed |
| Roskamp et al.
39
(2021) Other areas of dental research |
IL-6 (rs2069843) | IL-6 (rs2069843) | ______ |
| Bahirrah et al.
40
(2023) Orthodontics |
IL-IB (rs1143634) | ______ | IL-IB (rs1143634) |
| Marañón‐Vásquez et al.
41
(2023) Orthodontics |
VDR (rs1544410, rs7975232, rs731236, rs2228570) GC (rs4588) P450CYP27B1 (rs4646536) P450 CYP24A1(rs921650) |
VDR (rs2228570) P450 CYP27B1 (rs4646536) P450 CYP24A1- less expressive |
VDR (rs1544410, rs7975232, rs731236) GC (rs4588) |
| Silva et al.
42
(2022) Orthodontics |
TNFRSF11B gene, OPG (rs3102735) TNFRSF11A gene, RANK (rs1805034) IL-IB (rs1143634) P2RX7 (rs1718119) IL1RN (rs315952) |
TNFRSF11B gene, OPG (rs3102735) P2RX7 (rs1718119) IL1RN (rs315952) |
TNFRSF11A gene, encoding RANK (rs1805034) IL-IB (rs1143634) |
| Roskamp et al.
43
(2022) Other areas of dental research |
IL4(rs2227284/rs2243268) IL6(rs1524107/rs2069835/rs2069838/rs2069840/rs2069843/rs2069845) |
______ | IL4(rs2243268) |
| Baghaei et al.
44
(2023) Orthodontics |
IL-1A (rs1800587) IL-1B (rs1143634) \ IL-1RN (rs419598) P2RX7 (rs1718119, rs2230912 IRAK1 (rs1059703) CASP1 (rs530537, rs580253, rs554344) |
IL-1A (rs1800587) | IL-1B (rs1143634) IL-1RN (rs419598) P2RX7 (rs1718119, rs2230912), IRAK1 (rs1059703) CASP1 (rs530537, rs580253, rs554344) |
| *Iglesias-Linares et al.
47
(2012) Endodontics and Orthodontics |
IL1A(rs1800587) IL1B (rs1143634) |
IL1B (rs1143634) | IL1A (rs1800587) |
| Iglesias-Linares et al.
48
(2013) Endodontics and Orthodontics |
IL1RN (rs419598) | IL1RN (rs419598) | _____ |
| *Iglesias-Linares et al.
49
(2016) Other areas of dental research |
IL-1B (rs1143634) IL1A (rs1800587) IL1RN (rs419598) IL-6 (rs1800796) P2RX7 (rs208294, rs1718119, rs2230912) TNFRSF11B (OPG) TNFRSF11A (rs3102735, rs1805034) RANKL (rs228769) |
IL-1B (rs1143634) IL1A (rs1800587) P2RX7 (rs208294) TNFRSF11B (OPG) TNFRSF11A (rs3102735, rs1805034) RANKL (rs228769) |
IL1RN (rs419598) P2RX7 (rs1718119, rs2230912) |
EARR = external apical root resorption. IL-1A (-B, -RN, -4, -6) = interleukin α (-β, -receptor antagonist). P2XR7 = purinoreceptor P2X7. SPP1 = secreted phosphoprotein 1 or osteopontin. TNF- α = tumor necrosis factor α. RANK = Receptor activator of nuclear factor-κB RANK. TNFRSF11B = Tumour Necrosis Factor Receptor Superfamily Member 11a gene, encoding receptor activator of nuclear factor-κB RANK. TNFRSF11B = tumor necrosis factor receptor superfamily member 11B. TNSALP = tissue non-specific alkaline phosphatase. IRAK1 = Interleukin 1 Receptor Associated Kinase. CASP1/ICE = caspase-1/interleukin-converting enzyme. IL1RA = a interleukin-1 receptor antagonist. MDA5 = Melanoma Differentiation-Associated protein 5. IFIH1 = interferon induced with helicase C domain 1. IL1RN = interleukin 1 receptor antagonist gene. OPG = osteopontin gene. VDR = vitamin D receptor. CYP27B = cytochrome P450 family 27 subfamily B member 1. CYP24A1 = cytochrome P450 family 24 subfamily A member 1. STAG2 = stromalantigen2. RP1-30E17.2 = Clone-based(Vega)gene. SPP1 = osteopontin. *Most cited article, according to Figure 6.