Table 3: Analysis of revisions included in the bibliometrics.
| Authors/Year | Study Type | Conclusion |
|---|---|---|
| Pinheiro et al.
3
(2021) |
Systematic review and meta-analyses | Narrative analyses of individual studies demonstrated an association of many genes. The number of studies for each genetic variation was very low, and methodological heterogeneity between the studies was observed. The meta-analysis could only show an involvement for P2RX7 (rs208294) in the risk of orthodontic patients to EARR at a very low certainty of evidence according to GRADE |
| *Nowrin et al.
4
(2018) |
Systematic review and meta-analyses | More research on the relationship between gene polymorphism and EARR is necessary to determine better specificity of possible interactions. |
| Wu et al.
23
(2013) |
Meta-analyses | The variant genotypes (CC and CT) on polymorphism to IL-1B were not associated with EARR risk, compared with the wild-type TT homozygote |
| Aminoshariae et al.
24
(2016) |
Systematic review |
The current investigation suggests guidelines and recommendations for future investigators studying genetic polymorphism in patients undergoing orthodontic treatment |
| Nieto-Nieto et al.
45
(2017) |
Literature review | In recent years, international research groups have determined the degree of influence of some genetic biomarkers in the definition of increased/reduced susceptibility to post-orthodontic EARR. The influences of the gene cluster IL1 (IL1B, IL1A, IL1RN, IL6), P2RX7, CASP1, OPG (TNFRSF11B), RANK (TNFRSF11A), Osteopontin (OPN), TNFa, the vitamin D receptor (TaqI), TNSALP and IRAK1 were the most analyzed |
| Pereira et al.
46
(2018) |
Literature review | This study was performed searching for the association of rs1800587 from Interleukin-1 alpha (IL1A) gene and rs1143634 from interleukin-1 beta (IL1B) gene with EARR. In conclusion, suggests that for IL1B SNP rs1143634 and EARR have an opposite genetic profile. For IL1A, the hypothesis could not be confirmed |
| Behnaz et al.
50
(2020) |
Concise review | The rs1800587 and rs1143634 in IL-1A and IL-1B genes have been the mostly assessed SNPs in different populations. Yet, the results of investigations in different populations are not consistent. In this study, the authors summarize the results of studies that assessed the contribution of genetic factors in EARR. As genetic factors are involved in conferring risk of EARR, evaluation of these variants prior to establishment of orthodontic treatments might help in identification of at-risk individuals and better follow-up of these patients |
EARR = external apical root resorption. IL-1 (-A, -B, -RN, -6) = interleukin. P2XR7 = P2X7 purine receptor. TNF- α = tumor necrosis factor α. TNFRSF11A = tumor necrosis factor receptor superfamily member 11A, RANK. TNFRSF11B = tumor necrosis factor receptor superfamily member 11B. OPG = osteopontin gene. TNSALP = tissue non-specific alkaline phosphatase. IRAK1 = receptor-associated kinase interleukin 1. CASP1/ICE = caspase-1/interleukin-converting enzyme.
GRADE = Grading of Recommendations Assessment, Development, and Evaluation working group.
* Description of the most cited studies according to Figure 6.