Table 1.

Case series of untreated choroidal melanomas presented with subretinal exudation

	Age/sex	Eye	PMHx/POHx	Presenting VA	Final VA	Presenting symptoms	Location	SRF/IRF	U/S	OCT	Primary treatment	Histology genetics	Complication treatment
Case 1	39/M	RE	Unremarkable	6/4	6/18	Shadow in the visual field	SN	+	Medium reflectivity	Intraretinal and subretinal foci	Ruthenium plaque and transretinal biopsy	Spindle cell	Radiation maculopathy
									No Doppler				Anti-VEGF
									5.5 × 4.5 (3.0) mm	Subretinal exudates		Disomy 3 (MSA)
Case 2	52/F	RE	Spondylarthritis	6/7.5	6/7.5	Asymptomatic	SN	+	Low-medium reflectivity	Subretinal exudates	Ruthenium plaque and trans-scleral biopsy	Spindle cell	–
									Positive Doppler			Disomy 3
			Thyroid Cancer						11.98 × 10.78 (5.36) mm			(MLPA and MSA)
Case 3	47/F	LE	Unremarkable	6/6	N/A	Asymptomatic	Temporal to the macula	+	Low-medium reflectivity	Subretinal exudates	Ruthenium plaque	N/A	–
									7.58 × 7.60 (4.71) mm
Case 4	47/M	RE	Unremarkable	6/6	6/9	Asymptomatic	ST	+	Low reflectivity	Subretinal exudates	Ruthenium plaque	N/A	Radiation maculopathy
													Anti-VEGF
Case 5	41/M	LE	LE oculodermal melanosis	6/18	N/A	VA decrease	IT	+	Low reflectivity	Diffuse posterior pole exudates	Proton beam radiotherapy and transretinal biopsy and anti-VEGF	Spindle cell	Increased intraocular pressure
			LE CSCR						Positive Doppler				Vitreous haemorrhage
			RE amblyopia						10.77 × 8.66 (5.34) mm	Asteroid hyalosis		Disomy 3 (MSA)	Antiglaucoma drops
Case 6	55/F	RE	POAG	6/9	6/15	Asymptomatic	ST	+	Medium reflectivity	Subretinal haemorrhage and exudates	Proton beam radiotherapy	N/A	Radiation maculopathy and retinopathy
									10.67 × 9.54 (3.42) mm	Pigmented retinal infiltration			Pigmented vitreous infiltrates Ocular surface problems
Case 7	49/F	LE	LE choroidal naevus	6/6	6/7.5	Photopsias	Inferior juxtapapillary	+	Low reflectivity	Subretinal material and exudates	Proton beam radiotherapy	N/A	–
			Endometriosis
			Migraine						4.8 × 4.3 (1.42) mm
Case 8	79/M	LE	Hypertension	6/30	NLP	VA decrease, photopsias, floaters	S	+	Variable reflectivity	Retinal infiltration	Enucleation	Spindle cell	–
									(Apex medium-high, base medium-low)	Vitreous pigment
									10.1 × 7.8 (8.1) mm	Inferior subretinal exudates		Disomy 3 (MLPA and MSA)

M, male; F, female; RE, right eye; LE, left eye; SN, superonasally; ST, superotemporally; IT, inferotemporally; S, superiorly; MLPA, multiplex-ligation-dependent probe amplification; MSA, microsatellite analysis; VEGF, vascular endothelial growth factor; POAG, primary open-angle glaucoma; CSCR, central serous chorioretinopathy; NLP, no light perception; N/A, not available.