TABLE 2.
Multivariate analysis for predictors of disease‐free survival in CRC patients.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Sex (Male) | 1.47 | 0.98–2.21 | 0.07 | |||
| Age (>68 y a ) | 1 | 0.68–1.47 | 1 | |||
| Neoadjuvant therapy (yes) | 2.01 | 1.19–3.38 | 0.009* | 1.36 | 0.76–2.44 | 0.29 |
| Obstruction/perforation/abscess (present) | 1.65 | 0.8–3.41 | 0.17 | |||
| Histological type (undifferentiated) | 1.34 | 0.70–2.57 | 0.38 | |||
| Location (rectum) | 2.22 | 1.51–3.28 | 0.0001* | 2.25 | 1.46–3.48 | 0.0003* |
| T classification (pT3/4) | 3.17 | 1.96–5.12 | <0.0001* | 1.7 | 0.97–2.97 | 0.06 |
| Venous invasion (present) | 3.37 | 2.24–5.05 | <0.0001* | 2.15 | 1.37–3.36 | 0.0008* |
| Lymphatic invasion (present) | 2.89 | 1.79–4.67 | <0.0001* | 1.61 | 0.96–2.71 | 0.07 |
| Lymph node metastasis (present) | 2.73 | 1.85–4.02 | <0.0001* | 1.65 | 1.08–2.5 | 0.02* |
| High IBI status (>0.3333 b ) | 2.22 | 1.5–3.28 | 0.0001* | 1.75 | 1.16–2.64 | 0.007* |
Abbreviations: CI, confidence interval; CRC, colorectal cancer; HR, hazard ratio; IBI, Inflammatory Burden Index.
a
The median age at surgery was 68 y in this cohort.
b
Cutoff thresholds for IBI were determined by receiver operating characteristic curve analysis with Youden's index for overall survival for CRC patients.
*
p < 0.05.