TABLE 3.
Multivariate analysis for predictors of overall survival in CRC patients.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Sex (male) | 1.31 | 0.88–1.95 | 0.18 | |||
| Age (>68 y a ) | 0.97 | 0.66–1.42 | 0.86 | |||
| Neoadjuvant therapy (yes) | 1.88 | 1.17–3.03 | 0.009* | 1.17 | 0.7–1.93 | 0.55 |
| Obstruction/perforation/abscess (present) | 2.76 | 1.62–4.69 | 0.0002* | 1.52 | 0.87–2.64 | 0.14 |
| Histological type (undifferentiated) | 3.06 | 1.89–4.93 | <0.0001* | 2.63 | 1.6–4.34 | 0.0001* |
| Location (rectum) | 1.4 | 0.96–2.05 | 0.08 | |||
| T classification (pT3/4) | 4.59 | 2.57–8.2 | <0.0001* | 1.3 | 0.66–2.53 | 0.45 |
| Venous invasion (present) | 3.29 | 2.17–4.98 | <0.0001* | 1.63 | 1.01–2.63 | 0.05* |
| Lymphatic invasion (present) | 3.84 | 2.19–6.74 | <0.0001* | 1.48 | 0.78–2.8 | 0.23 |
| Lymph node metastasis (present) | 3.01 | 2.02–4.47 | <0.0001* | 1.09 | 0.7–1.7 | 0.7 |
| Distant metastasis (present) | 7.81 | 5.33–11.4 | <0.0001* | 4.51 | 2.91–7.01 | <0.0001* |
| High IBI status (>0.3333 b ) | 5.19 | 3.25–8.3 | <0.0001* | 2.83 | 1.71–4.67 | 0.0001* |
Abbreviations: CI, confidence interval; CRC, colorectal cancer; HR, hazard ratio; IBI, Inflammatory Burden Index.
a
The median age at surgery was 68 y in this cohort.
b
Cutoff thresholds for IBI were determined by receiver operating characteristic curve analysis with Youden's index for overall survival for CRC patients.
*
p < 0.05.