TABLE 5.
Multivariate analysis for predictors of surgical site infection in CRC patients.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | |
| Sex (male) | 0.95 | 0.62–1.48 | 0.84 | |||
| Age (>68 y a ) | 1.01 | 0.66–1.56 | 0.95 | |||
| Preoperative factor | ||||||
| Neoadjuvant therapy (yes) | 1.21 | 0.64–2.28 | 0.56 | |||
| Obstruction/perforation/abscess (present) | 2.28 | 1.13–4.58 | 0.02* | 1.57 | 0.75–3.28 | 0.23 |
| Oncological factor | ||||||
| Histological type (undifferentiated) | 0.79 | 0.36–1.74 | 0.56 | |||
| Location (rectum) | 1.06 | 0.68–1.64 | 0.81 | |||
| T classification (pT3/4) | 1.49 | 0.92–2.42 | 0.1 | |||
| Venous invasion (present) | 1.31 | 0.85–2.02 | 0.22 | |||
| Lymphatic invasion (present) | 1.24 | 0.78–1.98 | 0.37 | |||
| Lymph node metastasis (present) | 1.08 | 0.69–1.67 | 0.74 | |||
| Distant metastasis (present) | 0.89 | 0.5–1.58 | 0.69 | |||
| Preoperative blood test | ||||||
| High IBI status (>0.1025 b ) | 2.56 | 1.38–4.75 | 0.003* | 1.91 | 1.0–3.62 | 0.05* |
| Surgical factor | ||||||
| Open versus laparoscopic surgery (open) | 2.19 | 1.39–3.45 | 0.0008* | 1.44 | 0.79–2.62 | 0.23 |
| Operation time (>median) | 2.13 | 1.35–3.34 | 0.001* | 1.83 | 1.11–3.0 | 0.02* |
| Blood loss (>median) | 2.67 | 1.68–4.23 | <0.0001* | 1.53 | 0.82–2.84 | 0.18 |
Abbreviations: CI, confidence interval; CRC, colorectal cancer; IBI, Inflammatory Burden Index; OR, odds ratio.
a
The median age at surgery was 68 y in this cohort.
b
Cutoff thresholds for IBI were determined by receiver operating characteristic curve analysis with Youden's index for the presence of SSl in CRC patients.
*
p < 0.05.