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Histology of densely granulated somatotroph tumor. These tumors are composed of large cells with acidophilic cytoplasm, diffuse strong cytoplasmic reactivity for GH, nuclear positivity for PIT1, and diffusely distributed cytokeratin using the CK8/18 stain. HE, hematoxylin-eosin staining; GH, growth hormone; PIT-1, pituitary-specific transcription factor-1; CK8/18, cytokeratin 8/18.
