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Histology of sparsely granulated somatotroph tumor. These tumors are composed of large cells with chromophobic cytoplasms that harbor keratin aggresomes known as fibrous bodies and are positive for PIT-1. They have scant-variable cytoplasmic reactivity for GH and dots staining for CK8/18 in fibrous bodies. HE, hematoxylin-eosin staining; GH, growth hormone; PIT-1, pituitary-specific transcription factor-1; CK8/18, cytokeratin 8/18.
