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. Author manuscript; available in PMC: 2025 Sep 1.
Published in final edited form as: Allergy. 2024 Jul 24;79(9):2561–2564. doi: 10.1111/all.16257

Figure 1. Mast cell responses and food allergy are attenuated in OVA-challenged ST2−/− mice.

Figure 1.

WT and ST2−/− mice were sensitized and challenged with OVA as described in Supplemental Methods. One hour after the final challenge, mice were sacrificed, and the development of food allergy was assessed. (A) Percent of animals with diarrhea (B) Serum OVA-IgE (C) Jejunal mast cells (D) Serum MCPT-1 (E-F) Jejunal expression of IL-4 and IL-13 and (G-J) Expression of IL-4, IL5, IL-13 and IFN-γ following ex vivo stimulation of splenocytes by OVA for 72 hours. n=4–8 mice per group. Data are representative of 5 independent experiments. ND = not detected. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001 (Student’s t-test).