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. Author manuscript; available in PMC: 2025 Sep 1.
Published in final edited form as: Allergy. 2024 Jul 20;79(9):2502–2523. doi: 10.1111/all.16231

Figure 4. Hemolysis assay and correlation with anti-PEG antibody.

Figure 4.

(A) Higher anti-PEG IgG levels correlated with higher complement activation, and reflected in lower Avg RHA in allergic, high basophil responders (R2 = 0.5813, P = 0.028). (B) No correlation between anti-PEG IgM levels and Avg RHA (R2 = 0.056, P = 0.573) in allergic, high basophil responders. (C) Complement activation generated complement anaphylatoxin C3a following incubation of serum with COVID-19 mRNA vaccine leading to basophil activation, which was partially blocked by complement C3a receptor antagonist (C3aRA) (R2 = 0.5680, P = 0.031). (D) There is low correlation (R2= 0.2182, P = 0.243) between basophil response in the presence of C5aRA and Avg RHA in the allergic, high basophil responders.