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. Author manuscript; available in PMC: 2025 Sep 1.
Published in final edited form as: Allergy. 2024 Jul 20;79(9):2502–2523. doi: 10.1111/all.16231

Figure 6. Single cell multiome analyses on PBMCs identified contribution of the myeloid compartment on high basophil responders and low basophil responders.

Figure 6.

(A) Weighted nearest neighbor (WNN) UMAPs of predicted cell types based on azimuth classifications. Four subsets of cells within the myeloid compartment were identified (classical and non-classical monocytes, cDC2s and pDCs). (B) Top genes highly expressed within each clusters of cells identified. (C) Volcano plot to illustrate differentially expressed genes between high basophil responders versus low basophil responders versus non-allergics. (D) Heatmap and violin plots denoting a selection of genes differentially expressed within the myeloid compartment of differen study subjects. (E) Pathway enrichment analysis in high basophil responders vs. low basophil responders, high basophil responders vs non-allergics and low basophil responders vs non-allergics. (F) Peak callings to illustrate accessible regions within the IL-13, IL-4, and IL-1B loci of high basophil responders, low basophil responders and non-allergics.