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CdaA (TDE1909) synthesizes c-di-AMP from ATP and CdaA activity is likely regulated by CdaR (TDE1908). Intracellular levels of c-di-AMP are maintained by the PDE DhhA (TDE0027) and possibly PgpH (TDE1241). C-di-AMP binds to a putative potassium uptake protein, TrkA (TDE0087), and may inhibit the import of potassium into the cell under hypoosmotic stress.
