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Photomicrograph of liver of the control group (A) and AN group (B) showing negative immunoreactivity of COX-2 in hepatocytes. In C, the photomicrograph of liver in gentamicin injected rats showing significant increase of COX2 positive hepatocytes (arrows). In D, the photomicrograph of liver of the gentamicin + AN treated group showed a marked decrease in COX2-positive brown stains (arrows). COX-2 IHC, bar = 50 μm.
