Figure 7.

Effect of tofacitinib (JAK inhibitor) in mouse DSS-induced colitis

(A) Time course analysis of body weight changes of mice in all experimental groups. Gray shade (from day 0 to day 5) indicates presence of DSS in drinking water. Arrow heads indicate doses of vehicle or tofacitinib. Individual dots represent the relative weigh of each animal compared to day 0. ^∗∗ for p < 0.01 at day 10 by two-way ANOVA followed by Šídák’s multiple comparisons test.

(B) Swiss roll sections of colon from control and DSS groups as indicated in (A). Sections were stained with hematoxylin & eosin (H&E). Scale bar: 600 μm.

(C) Assessment of tissue damage in the histological preparations. Left plot shows length of epithelial erosions from H&E staining. Right plot shows total length of the colon for comparison. Individual dots represent the values for individual animals at day 10.