Figure 2.

Transcriptional analysis of reactive hPSC-derived astrocytes compared to controls

(A) Heatmap representing differentially expressed genes in reactive and control astrocytes. The up- and downregulated genes are represented as red and blue colored, respectively.

(B) Volcano plot exhibiting differentially expressed genes in reactive astrocytes compared to controls. Significantly upregulated genes are shown in blue, while significantly downregulated genes are shown in green.

(C and D) GO and pathway analysis based on differential gene expression of reactive and control astrocytes.