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. 2024 Jul 25;19(8):1053–1060. doi: 10.1016/j.stemcr.2024.06.012

Figure 2.

Figure 2

BiPOLES cardiomyocyte transplantation partially remuscularized the injured heart

(A and B) Short-axis sections of a heart eight weeks after cardiomyocyte transplantation stained for dystrophin (A) and human Ku80 (B). Inset in B is shown in higher magnification on the right.

(C–F) Graft-host interaction in lower and higher magnification. Grafts are visualized with mCerulean staining (C and D). Asterisks mark structural graft-host coupling (E and F).

(G and H) High-magnification images showing (G) connexin 43 and (H) N-cadherin expression in the human grafts. Higher magnification depicts the inset to visualize an intercalated-disc-like structure.

(I) Analysis of cell-cycle activity. Each data point represents one heart. Four images per heart were used for quantification. Data is represented as mean ± SEM. Asterisks mark human nuclei in the cell cycle.

(J) Staining for myosin light-chain isoform expression.

(K) Staining for troponin I isoform expression. Quantification for (E) and (F) was based on pixel area per image. Four images per heart from three different hearts were used for quantification. Scale bars: 2 mm in (A) and (B). 100 μm in (B) (high magnification) and 10 μm in (C–K).