Figure 3.

Transcriptional differences between microgravity and gravity control biomimetic skeletal muscle

(A) Principal-component analysis of the transcriptome of biomimetic skeletal muscle samples after 7 days in microgravity or control conditions (gravity).

(B) Heatmap shows all differentially expressed genes after 7 days in microgravity, compared to gravity (FDR 10%).

(C) Gene Ontology (GO) enrichment terms of differentially upregulated genes in microgravity (p < 0.05).

(D) Heatmap shows the expression of genes found in the mitochondrion GO enrichment term.

(E) Pathway enrichment terms of differentially upregulated genes in microgravity (p < 0.05).

(F) Pathway enrichment terms of differentially downregulated genes in microgravity (p < 0.05).

(G) Heatmap shows expression of top 20 differentially downregulated genes in microgravity (n = 2 donors per group).