Figure 2.

MeCP2 chromatin immunoprecipitation sequencing and proteomic assays on MGL

(A) Explanatory schematic of CTRL, KO^R, and KO MGLs regarding the role of MeCP2.

(B) Venn diagram of MeCP2 occupation peaks between CTRL and KO^R.

(C) Annotation distribution of MeCP2 target peaks.

(D) Top canonical pathways for the promoter-TSS region obtained using IPA, where significance was calculated by the right-tailed Fisher’s exact test (p < 0.05).

(E) A table highlighting several MECP2 targets of interest in the genome.

(F and G) Top 5 known and de novo motifs obtained with MeCP2 ChIP-seq in MGLs.

(H) LC-MS proteomic analyses conducted on MGL shows 480 overlapping candidates with MeCP2 ChIP-seq in the promoter region.

(I) Top canonical pathways of the intersecting candidates between proteomics and ChIP-seq obtained through IPA (p < 0.05).