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. 2024 Aug 3;16(8):e66088. doi: 10.7759/cureus.66088

Table 3. Clinicohistopathological correlation of biomarker expressions.

p53: Tumor protein p53; EGFR: estimated glomerular filtration rate; CK20: cytokeratin 20

Biomarker Histological Subtype p-value
p53
-Urothelial carcinoma Positive: 105 (73.9) <0.001
Negative: 37 (26.1)
-Squamous cell carcinoma Positive: 12 (50.0) 0.021
Negative: 12 (50.0)
Ki-67
-Urothelial carcinoma High: 96 (67.6) <0.001
Low: 46 (32.4)
-Squamous cell carcinoma High: 20 (83.3) 0.005
Low: 4 (16.7)
EGFR
-Urothelial carcinoma Overexpression: 84 (59.2) <0.001
Normal expression: 58 (40.8)
-Squamous cell carcinoma Overexpression: 10 (41.7) 0.042
Normal expression: 14 (58.3)
CK20
-Urothelial carcinoma Positive: 120 (84.5) <0.001
Negative: 22 (15.5)
-Squamous cell carcinoma Positive: 10 (41.7) 0.018
Negative: 14 (58.3)