Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

editorial

. 2024 Aug 20;11:1464672. doi: 10.3389/fmed.2024.1464672

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Bunik.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Relationship between the disease causing genes and phenotypes. (A) In general, defects in different genes may converge to the same symptoms, with multiple disease phenotypes potentially observed at even the same defect of one gene. (B) Illustration of the relationship in (A) by specific case of congenital lactic acidosis and its phenotypes caused by impairments of the pyruvate dehydrogenase multienzyme complex due to defective genes PDHA and PDHX, encoding for the α-subunit of the pyruvate dehydrogenase and protein X, correspondingly. See text for further explanations.