TABLE 4.
The results of Meta-regression.
| Heterogeneity source | Coefficient | 95%CI | Z | P | ||
|---|---|---|---|---|---|---|
| FokI (rs2228570) | ||||||
| Ethnicity | Allele (f vs. F) | Asian (reference) | - | - | - | - |
| European | −0.446 | (-0.948,0.056) | −1.742 | 0.082 | ||
| North American | −0.876 | (-1.523,-0.229) | −2.654 | 0.008 | ||
| South American | −0.408 | (-0.934,0.118) | −1.521 | 0.128 | ||
| Dominant (ff + Ff vs. FF) | Asian (reference) | - | - | - | - | |
| European | −0.615 | (-1.234,0.003) | −1.951 | 0.051 | ||
| North American | −1.236 | (-2.041,-0.431) | −3.010 | 0.003 | ||
| South American | −0.834 | (-1.569, −0.098) | −2.221 | 0.026 | ||
| Recessive (ff vs. Ff + FF) | Asian (reference) | - | - | - | - | |
| European | −0.553 | (-1.400,0.295) | −1.278 | 0.201 | ||
| North American | −1.011 | (-2.021, −0.001) | −1.961 | 0.049 | ||
| South American | −0.390 | (-1.230,0.450) | −0.911 | 0.363 | ||
| Homozygote (ff vs. FF) | Asian (reference) | - | - | - | - | |
| European | −0.875 | (-1.875,0.124) | −1.716 | 0.086 | ||
| North American | −1.619 | (-2.857, −0.381) | −2.563 | 0.010 | ||
| South American | −0.955 | (-2.020,0.110) | −1.758 | 0.079 | ||
| Publication year | f vs. F | 0.011 | (-0.0257,0.0485) | 0.602 | 0.548 | |
| ff + Ff vs. FF | 0.021 | (-0.032,0.073) | 0.761 | 0.447 | ||
| ff vs. Ff + FF | 0.001 | (-0.053,0.056) | 0.052 | 0.959 | ||
| ff vs. FF | 0.012 | (−0.064,0.087) | 0.306 | 0.760 | ||
| BsmI (rs1544410) | ||||||
| Ethnicity | Allele (b vs. B) | Asian (reference) | - | - | - | - |
| European | −0.480 | (-1.275,0.315) | −1.183 | 0.237 | ||
| North American | 0.012 | (-1.033,1.057) | 0.023 | 0.982 | ||
| Dominant (bb + Bb vs. BB) | Asian (reference) | - | - | - | - | |
| European | −1.075 | (-2.105, −0.046) | −2.048 | 0.041 | ||
| North American | −0.320 | (-1.566,0.926) | −0.504 | 0.614 | ||
| Recessive (bb vs. Bb + BB) | Asian (reference) | - | - | - | - | |
| Heterogeneity source | Coefficient | 95%CI | Z | P | ||
| Homozygote (bb vs. BB) | European | −0.452 | (-1.681,0.777) | −0.720 | 0.472 | |
| North American | −0.048 | (-1.833,1.736) | −0.053 | 0.958 | ||
| Asian (reference) | - | - | - | - | ||
| European | −1.407 | (-2.598, −0.217) | −2.317 | 0.021 | ||
| North American | −0.690 | (-2.323,0.943) | −0.828 | 0.408 | ||
| Publication year | b vs. B | −0.010 | (-0.082,0.063) | −0.268 | 0.789 | |
| bb + Bb vs. BB | −0.061 | (-0.158,0.037) | −1.223 | 0.221 | ||
| bb vs. Bb + BB | 0.023 | (-0.087,0.134) | 0.409 | 0.683 | ||
| bb vs. BB | −0.021 | (-0.158,0.117) | −0.293 | 0.770 | ||
| TaqI (rs731236) | ||||||
| Ethnicity | Allele (t vs. T) | Asian (reference) | - | - | - | - |
| European | −0.456 | (-1.499,0.588) | −0.856 | 0.392 | ||
| North American | −0.003 | (-0.887,0.881) | −0.007 | 0.994 | ||
| South American | −0.332 | (-1.103,0.439) | −0.844 | 0.399 | ||
| Dominant (tt + Tt vs. TT) | Asian (reference) | - | - | - | - | |
| European | −0.468 | (-1.712,0.776) | −0.738 | 0.461 | ||
| North American | −0.059 | (-1.074,0.956) | −0.113 | 0.910 | ||
| South American | −0.431 | (-1.304,0.443) | −0.966 | 0.334 | ||
| Recessive (tt vs. Tt + TT) | Asian (reference) | - | - | - | - | |
| European | −1.283 | (-2.917,0.351) | −1.539 | 0.124 | ||
| North American | 0.085 | (-1.118,1.287) | 0.138 | 0.890 | ||
| South American | 0.115 | (-1.988,2.218) | 0.107 | 0.915 | ||
| Homozygote (tt vs. TT) | Asian (reference) | - | - | - | - | |
| European | −1.715 | (-3.690,0.261) | −1.701 | 0.089 | ||
| North American | −0.001 | (-1.502,1.500) | −0.001 | 0.999 | ||
| South American | −0.148 | (-2.367,2.071) | −0.131 | 0.896 | ||
| Publication year | t vs. T | −0.013 | (-0.058,0.033) | −0.549 | 0.583 | |
| tt + Tt vs. TT | −0.005 | (-0.052,0.042) | −0.214 | 0.830 | ||
| tt vs. Tt + TT | −0.086 | (-0.184,0.012) | −1.728 | 0.084 | ||
| tt vs. TT | −0.097 | (-0.215,0.021) | −1.612 | 0.107 | ||
The bold values indicate that the OR (95%CI) does not include 1, and the p-value is <0.05.