Figure 3.

Activation of moDCs by a set of therapeutic antibodies. Each sub-figure represents the stimulation index (SI) for a particular surface marker and the dotted line corresponds to 1 (value for the medium treated condition). The SI was calculated for each donor/surface marker pair using the corresponding medium treated control as described in the Material and Methods section. Each individual donor tested is indicated by a different color (n=10) and a one-sided paired t test was applied for the comparison of antibodies against the medium treated control (p< 0.01**; p< 0.05*) displayed along with a one-sided confidence interval (level = 0.95). Additionally, a paired one-sided t test between the PCSK9 targeting antibodies (alirocumab, evolocumab and bococizumab) was performed (p< 0.01**; p< 0.05*; not significant, ns).